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This paper describes a set of comparative experiments, including cross-corpus evaluation, between five alternative algorithms for supervised Word Sense Disambiguation (WSD), namely Naive Bayes, Exemplar-based learning, SNOW, Decision Lists, and Boosting. Two main conclusions can be drawn: 1) The LazyBoosting algorithm outperforms the other four state-of-the-art algorithms in terms of accuracy and ability to tune to new domains; 2) The domain dependence of WSD systems seems very strong and suggests that some kind of adaptation or tuning is required for cross-corpus application.